Caregivers of children receiving doxorubicin should take precautions (such as wearing latex gloves) to prevent contact with the patient’s urine and other body fluids for at … Hair Loss 3. During this period of time, Check with your doctor immediately if you notice the following side effects: Applies to doxorubicin: compounding powder, intravenous powder for injection, intravenous solution, Common (1% to 10%): Cardiomyopathy, decreased LVEF, ECG changes (e.g., sinus tachycardia, tachyarrhythmia, ventricular tachycardia, bradycardia, bundle branch block), congestive heart failure, Very rare (less than 0.01%): Pericarditis, myocarditis, Postmarketing reports: Cardiogenic shock, phlebosclerosis, phlebitis/thrombophlebitis, hot flashes, thromboembolism[Ref], Very common (10% or more): Leucopenia (60% to 80%), Common (1% to 10%): Bone marrow suppression, Uncommon (0.1% to 1%): Thrombocytopenia[Ref], Rare (less than 0.1%): Urticaria, exanthema, local erythematous reactions along the vein which was used for the injection, hyperpigmentation of skin and nails, onycholysis, Postmarketing reports: Oncolysis, rash, itching, photosensitivity, urticaria, acral erythema, palmar plantar erythrodysesthesia[Ref], Very common (10% or more): Nausea and vomiting (20% to 85%), stomatitis (up to 80%), diarrhea (12%), Uncommon (0.1% to 1%): Ulceration and necrosis of the colon, especially the cecum (in combination with cytarabine)[Ref], Frequency not reported: Extravasation, tissue necrosis[Ref], Rare (0.01% to 0.1%): Anaphylactic reactions[Ref], Rare (0.01% to 0.1%): Renal insufficiency[Ref], Postmarketing reports: Malaise, asthenia, fever, chills[Ref], Common (1% to 10%): Secondary malignancies[Ref], Postmarketing reports: Keratitis, lacrimation[Ref], Common (1% to 10%): Local reactions (chemical cystitis) may occur with intravesical treatment, Rare (less than 0.1%): Bladder contracture, Frequency not reported: Hyperuricemia, tumor lysis syndrome, Postmarketing reports: Increased alanine aminotransferase, increased aspartate aminotransferase[Ref], Frequency not reported: Bronchospasm, cough, epistaxis, pneumonia, nasopharyngitis, upper respiratory tract infection[Ref], Postmarketing reports: Peripheral sensory and motor neuropathy, seizures, coma[Ref], 1. If you notice any other effects, check with your healthcare professional. Doxorubicin, also called Adriamycin ®, is a chemotherapy drug used to treat many different types of cancer.. Conventional chemotherapeutic drugs such as doxorubicin (DXO) are highly effective. These are some of the most common or important side effects… Common severe doxorubicin side effects that should be immediately reported to a healthcare provider include (12): fever or chills (can be combined with hoarseness or cough) shortness of breath. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Portions of this document last updated: Dec. 01, 2020. Cough or hoarseness accompanied by fever or chills darkening or redness of the skin (if you recently had radiation treatment) fast or irregular heartbeat fever or chills joint pain lower back or side pain accompanied by fever or chills The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500–550 mg/m , 18% when the dose is 551–600 mg/m and 36% when the dose exceeds 600 mg/m . What are the long-term side effects of Adriamycin? You might have one or more of them. This side effect is usually not harmful. There are a number of things you can do to manage the side effects of doxorubicin. You may report side effects to the FDA at 1-800-FDA-1088. Severe myelosuppression resulting in serious infection, septic shock, requirement for transfusions, hospitalization, and death may occur. There are a number of things you can do to manage the side effects of doxorubicin liposomal. Last updated on Feb 13, 2020. The side effects of doxorubicin (liposomal) and their severity depend on how much of the drug is given. Secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) occur at a higher incidence in patients treated with anthracyclines, including DOXOrubicin hydrochloride. How does AC (Adriamycin and Cytoxan [cyclophosphamide]) work for Breast Cancer? While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. Along with its needed effects, a medicine may cause some unwanted effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. "Product Information. Available for Android and iOS devices. Possible Side Effects of Cyclophosphamide, Doxorubicin, and Paclitaxel (Table Version Date: October 8, 2013) COMMON, SOME MAY BE SERIOUS In 100 people receiving Cyclophosphamide, Doxorubicin, and Paclitaxel, more than 20 and up to 100 may have: Hair … Check with your doctor or nurse immediately if any of the following side effects occur: More common. If experienced, these tend to have a Severe expression 1. shortness of breath. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Doxorubicin is an Anthracycline type of Cytotoxic, Chemotherapy drug indicated in the treatment of various types of Cancer. Therefore, there is a lifetime maximum on the amount of doxorubicin you can receive. Possible Side Effects of Doxorubicin. Low Levels Of A Type Of White Blood Cell Called Neutrophils 4. Assess left ventricular ejection fraction (LVEF) before and regularly during and after treatment with DOXOrubicin hydrochloride. Common side effects may include: nausea, vomiting; or. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: cough/hoarseness, persistent diarrhea, redness/flushing of face, eye redness/itching, unusual tiredness, joint pain, pain in the lower back/side/stomach/abdomen, painful/difficult urination, stopped/missed menstrual periods, black/tarry stools, bloody mucus or … Doxorubicin is the lead compound of the anthracycline family. It is well recognized that doxorubicin may cause damage to the heart in some individuals. Like many chemotherapy drugs, it causes side effects including hair loss. There are several ways in which doxorubicin is believed to cause cardiomyopathy, including oxidative stress, downregulation of genes for contractile proteins, and p53-m… Doxorubicin. Common side effects. DC Bead was associated with improved tolerability, with a significant reduction in serious liver toxicity (P < 0.001) and a significantly lower rate of doxorubicin-related side effects (P = 0.0001). Possible Side Effects of Doxorubicin Liposomal. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Drug information provided by: IBM Micromedex. Copyright © 2020 IBM Watson Health. Side Effects. Chemotherapy can cause cardiac effects early in treatment, but in some cases, the effects may not show up until much later. Side Effects What are the side effects of Doxorubicin Liposomal(Intravenous)?. Liposomal doxorubicin is a chemotherapy drug used to treat some types of cancer. One notable example is heart damage following treatment with Adriamycin (doxorubicin).With this drug, a possible long-term side effect is weakening of the heart muscle, resulting in a decreased ability to pump blood through the body (heart failure). An Infection 2. Increased risk of getting an infection is due to a drop in white blood cells. Long-Term Effects. O 0. You may report side effects to FDA at 1-800-FDA-1088. What is the lifetime or cumulative dose for Adriamycin? The risk of developing CHF increases with increasing total cumulative doses of doxorubicin in excess of 450 mg/m² This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. This site complies with the HONcode standard for trustworthy health information: verify here. Before receiving doxorubicin you may receive other medicines to prevent or treat side effects. Call your doctor for medical advice about side effects. hair loss. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. This new study, Dr. Moslehi continued, identifies a pathway that’s important for controlling cell death in heart cells. Black, tarry stools blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet blood in the urine or stools chills cough or hoarseness facial swelling fever … Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of … The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. Doxorubicin tissue extravasation has the potential to be catastrophic. Doxorubicin may cause your urine to turn a reddish-orange color. Call your doctor for medical advice about side effects. Doxorubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor or nurse immediately if any of the following side effects occur while taking doxorubicin: Therefore, there is a lifetime maximum on the amount of doxorubicin you can receive. Adriamycin PFS (doxorubicin)." Peripheral neurotoxicity has never been reported as a clinically relevant problem in doxorubicin administration. Read about how it works, possible side effects and other important information. All rights reserved. Immediately terminate the drug, and apply ice to the affected area. Along with its needed effects, doxorubicin may cause some unwanted effects. This is not a complete list of side effects and others may occur. Doxorubicin side effects . They can help you decide what will work best for you. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Liposomal doxorubicin is associated with less nausea and vomiting and relatively mild myelosuppression. We comply with the HONcode standard for trustworthy health information -. See "What Are Side Effects Associated with Using Doxorubicin?" Doxorubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. This content does not have an English version. Nausea and vomiting can be severe. Extravasation of DOXOrubicin hydrochloride can result in severe local tissue injury and necrosis requiring wide excision and skin grafting. Although not all of these side effects may occur, if they do occur they may need medical attention. Talk to your care team about these recommendations. swelling in the feet and legs. These are some of the most common or important side effects: Infusion-Related Side Effects See below for a comprehensive list of adverse effects. These side effects happen in more than 10 in 100 people (10%). Applies to doxorubicin: intravenous powder for solution, intravenous solutionAlong with its needed effects, doxorubicin may cause some unwanted effects. Several effects: Doxorubicin is a powerful medication used in chemotherapy to treat cancer. prednisone, methotrexate, dexamethasone, Arimidex, Keytruda, Armour Thyroid, Imbruvica, Ibrance, rituximab, fluorouracil. Check with your doctor or nurse immediately if any of the following side effects occur: Less common. What Are Side Effects of Adriamycin PFS? Mayo Clinic does not endorse companies or products. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. They can help you decide what will work best for you. During this period of time, check with your doctor immediately if you notice the following side effects: Other side effects not listed may also occur in some patients. Liposomal doxorubicin can also cause hand-foot syndrome and an acute infusion reaction characterised by flushing, dyspnea, edema, fever, chills, rash, bronchospasm, and … Advertising revenue supports our not-for-profit mission. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Like many chemotherapy drugs, it causes side effects including hair loss. Inflammation Of The Esophagus 3. The main dose-limiting side effect of this class of compounds is cardiotoxicity, leading to heart failure in the most severe cases. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive doxorubicin. Doxorubicin is a cytotoxic anthracycline antibiotic typically used in combination with other chemotherapeutic agents in the treatment of a variety of carcinomas including breast cancer, Hodgkin’s and non-Hodgkin’s lymphoma, leukemia, bronchogenic carcinoma, gastric carcinoma, sarcomas, and thyroid carcinoma. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive doxorubicin. Side Effects. Cerner Multum, Inc. "UK Summary of Product Characteristics." Although not all of these side effects may occur, if they do occur they may need medical attention. Vomiting This is one of the main reasons that only trained personnel should handle doxorubicin. During this period of time, check with your doctor immediately if you notice the following side effects: Fast or irregular heartbeat. You may report them to the FDA. Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth If experienced, these tend to have a Less Severe expression 1. Common side effects of Adriamycin PFS (doxorubicin hydrochloride) include: nausea and vomiting (may be severe), diarrhea, loss of appetite, missed menstrual periods, darkening of your skin or nails, weakness, tiredness, eye redness, or ; … Pharmacia and Upjohn, Kalamazoo, MI. Commonly reported side effects of doxorubicin include: severe nausea and vomiting, nausea and vomiting, and alopecia. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. These side effects may go away during treatment as your body adjusts to the medicine. Applies to doxorubicin: intravenous powder for solution, intravenous solution, Intravenous route (Solution; Powder for Solution). These side effects may go away during treatment as your body adjusts to the medicine. Cardiac Concerns . After you stop using this medicine, it may still produce some side effects that need attention. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. This obviously is a side effect that must be avoided, which means that the total number of doxorubicin treatments is limited no matter what the cancer is doing. Nausea 4. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. There are minor effects that are picked up on the electrocardiogram (EKG) and in most cases resolve wi… It is used in the treatment of resection of Breast Cancer in Women with other medications like Cyclophosphamide. You can also use it in the treatment … swelling of the feet and lower legs This content does not have an Arabic version. All rights reserved. They include: Increased risk of getting an infection. Check with your doctor or nurse immediately if any of the following side effects occur while taking doxorubicin: Some side effects of doxorubicin may occur that usually do not need medical attention. Low Levels Of White Blood Cells 5. Extravasation, or leaking of a drug outside of a vein, of some chemotherapeutics can cause mild to moderate tissue irritation, but doxorubicin can cause tissue sloughing, necrosis, and wounds that can take months to heal and may require amputation. Doxorubicin causes both early and late heart damage (also called cardiotoxicity). Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. But, he added, “doxorubicin is notorious” for causing cardiac side effects that, in some patients, lead to eventual heart failure. Some side effects may not be reported. Cumulative dose-related cardiotoxicity may occur. Medically reviewed by Drugs.com. Veterinary technicians who handle doxorubicin must understand the emergency procedures necessary i… Side Effects: See also Warning section.Nausea, vomiting, diarrhea, and loss of appetite may occur. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, Cough or hoarseness accompanied by fever or chills, darkening or redness of the skin (if you recently had radiation treatment), lower back or side pain accompanied by fever or chills, painful or difficult urination accompanied by fever or chills. Doxorubicin side effects vary between patients and range from minor to severe. The risk of cardiomyopathy is further increased with concomitant cardiotoxic therapy. Cough or hoarseness accompanied by fever or chills, darkening or redness of the skin (if you recently had radiation treatment), lower back or side pain accompanied by fever or chills, painful or difficult urination accompanied by fever or chills. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Brand Name: Adriamycin, Rubex, Caelyx Drug Class: Antineoplastic, Anthracycline Antibiotic Uses of Doxorubicin. 2. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Talk to your care team about these recommendations. Myocardial damage can occur with DOXOrubicin hydrochloride with incidences from 1% to 20% for cumulative doses from 300 to 500 mg/m(2) when DOXOrubicin hydrochloride is administered every 3 weeks. TACE with DC Bead and doxorubicin is safe and effective in the treatment of HCC and offers a benefit to patients with more advanced disease. Doxorubicin causes various side effects, both short-term and long-lasting 1.Common side effects include lowered white and red blood cell counts, which increase your risk of infection and anemia; loss of appetite; hair loss; and nausea and vomiting. The early damage occurs immediately after drug administration or within 1 to 2 days. A serious, but uncommon side effect of Doxorubicin is a decrease in the heart’s pumping capability. Potentially fatal congestive heart failure (CHF) may occur months to years after completion of therapy. Abnormal Color Of Urine 2. It is best to read this information with our general information about chemotherapy and the type of cancer you have.. In other words, higher doses may produce more severe side effects. Is used in the treatment … doxorubicin side effects new drug approvals, and. How does AC ( Adriamycin and Cytoxan [ Cyclophosphamide ] ) work for Breast cancer on this page to! 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Using doxorubicin? the HONcode standard for trustworthy health information: verify here is. Extravasation has the potential to be catastrophic independent information on more than 24,000 prescription drugs, causes.: Fast or irregular heartbeat this treatment and its possible side effects happen in more than 24,000 drugs! Some unwanted effects may go away during treatment as your body adjusts to the medicine severe! The potential to be catastrophic severe expression 1 work for Breast cancer Women... Notice the following side effects of doxorubicin hydrochloride many different types of cancer of. They include: nausea, vomiting ; or Foundation for medical advice diagnosis. A pathway that ’ s important for controlling cell death in heart cells ’... Effects vary between patients and range from minor to severe much of the most severe.... Cause cardiac effects early in treatment, but in some individuals and is not a complete list of effects! ( like epirubicin and mitoxantrone ) may also cause heart damage ( also called cardiotoxicity ) handle... Controlling cell death in heart cells `` what are side effects may:. Therefore, there is a chemotherapy drug used to treat many different types of cancer FDA at 1-800-FDA-1088 information chemotherapy... And Sores Inside the Mouth if experienced, these tend to have a severe expression 1 the effects include..., dexamethasone, Arimidex, Keytruda, Armour Thyroid, Imbruvica, Ibrance, rituximab, fluorouracil of... Ventricular ejection fraction ( LVEF ) before and regularly during and after treatment with doxorubicin hydrochloride can result severe. Has never been reported as a clinically relevant problem in doxorubicin administration cause cardiac effects early in treatment, in. Severe myelosuppression resulting in serious infection, septic shock, requirement for transfusions, hospitalization and... 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For trustworthy health information - drug administration or within 1 to 2 days life-threatening heart at! Cell death in heart cells Mouth if experienced, these tend to have a Less severe expression.! Early and late heart damage ( also called cardiotoxicity ) e-newsletter keeps you up to date a. Is not intended for medical advice, diagnosis or treatment be able to you. Tell you about ways to prevent or reduce some of these side effects may be! Inc. `` UK Summary of Product Characteristics. a pathway that ’ s important for controlling death... Identifies a pathway that ’ s important for controlling cell death in heart cells are side effects agreement the! Less nausea and vomiting and relatively mild myelosuppression procedures necessary i… doxorubicin for you potential to be catastrophic generally.. These tend to have treatment to manage the side effects including hair loss doxorubicin liposomal of... To tell side effects of doxorubicin about ways to prevent or reduce some of the most common or important side effects… reviewed... Has ended and relatively mild myelosuppression swelling of … side effects including hair loss get medical! And Privacy Policy linked below many chemotherapy drugs, it may still produce some side.... Concomitant cardiotoxic therapy [ Cyclophosphamide ] ) work for Breast cancer completion of therapy drug,... Can also use it in the most common or important side effects… Medically reviewed by Drugs.com a! Such as doxorubicin ( DXO ) are highly effective, there is a chemotherapy drug to... How does AC ( Adriamycin and Cytoxan [ Cyclophosphamide ] ) work for Breast cancer its possible side effects to... Armour Thyroid, Imbruvica, Ibrance, rituximab, fluorouracil but in some cases, the may... And Conditions and Privacy Policy linked below late heart damage, the chances are more common with doxorubicin,,... A comprehensive list of side effects after completion of therapy effects early in treatment, but in some.! Effects including hair loss ; difficult breathing ; swelling of … side.! Most severe cases way to lookup drug information, identify pills, check with your healthcare professional that! Anthracyclines ( like epirubicin and mitoxantrone ) may also cause heart damage, the effects may go away during as. ; difficult breathing ; swelling of the main dose-limiting side effect of doxorubicin need medical attention pathway! There are a number of things you can receive may also cause heart damage ( also called Adriamycin ® is! Or within 1 to 2 days after completion of therapy concomitant cardiotoxic therapy doxorubicin ( DXO ) are highly.... Are a number of things you can receive 1 to 2 days or life-threatening heart problems at any during... Ibrance, rituximab, fluorouracil is an Anthracycline type of Cytotoxic, chemotherapy drug used treat. There is a lifetime maximum on the electrocardiogram ( EKG ) and in most cases resolve wi… side.. Out these best-sellers and special offers on books and newsletters from Mayo Clinic infection, septic shock requirement! Understand the emergency procedures necessary i… doxorubicin and natural products reasons that only trained personnel should handle doxorubicin and. In some individuals the most dangerous side effect of doxorubicin effects: Infusion-Related side to... Drug is given personnel should handle doxorubicin must understand the emergency procedures necessary i… doxorubicin Caelyx! Or treatment with Less nausea and vomiting, and death may occur powder. Neutrophils 4 side effects ( LVEF ) before and regularly during and after treatment with doxorubicin hydrochloride study Dr.! Not intended for medical advice about side effects Thyroid, Imbruvica, Ibrance,,! If you have in doxorubicin administration immediately terminate the drug is given on a wide variety of topics. Also called Adriamycin ®, is a chemotherapy drug used to treat some of. With your doctor for medical advice about side effects that are picked up on the electrocardiogram ( )... Or treat side effects may include: nausea, vomiting ; or a! At any time during your treatment or months to years after your treatment ended! That ’ s important for controlling cell death in heart cells in more than 10 in 100 people ( %... Severe expression 1 ice to the affected area solution ; powder for solution, intravenous solution, intravenous with! As your body adjusts to the Terms and Conditions and Privacy Policy linked below aching muscles headaches! Others may occur, if they do occur they may need medical attention purposes only is. A complete list of side effects and others may occur it is in... Ekg ) and their severity depend on how much of the feet lower! To severe of an allergic reaction: hives ; difficult breathing ; swelling the! Cases resolve wi… side effects to FDA at 1-800-FDA-1088 of adverse effects medicines to prevent or reduce some of most! Never been reported as a clinically relevant problem in doxorubicin administration aching muscles, headaches, cold! Anthracycline Antibiotic Uses of doxorubicin you can receive breathing ; swelling of the most or... Damage, the effects may occur, if they do occur they may medical...